What I will learn?

• At the conclusion of this activity participants will be able to:
• Ynderstand why increased maternal venous pressures may occur while supine, how this may affect uteroplacental perfusion vis-a-vis the organ perfusion pressure equation, and why avoiding supine positioning may be especially important in patients with certain clinically identifiable features (e.g., obesity, polyhydramnios, obstructive sleep apnea).
• Understand the clinical significance of pontosubicular neuronal necrosis (PSN), which is indicative of survivable hypoxic ischemic brain injury that would have occurred approximately 12-24 hours prior to death due to uteroplacental hypoperfusion. Presumably, the insulting event reoccurred and led to fetal demise due to recurrent uteroplacental hypoperfusion episodes associated with the clinically identifiable features, and thus represents evidence of a clinically relevant process that may be modifiable.