Stillbirths are a devastating tragedy. Although fetal autopsies and placental pathologies may yield diagnostic information regarding the cause, between 10-50% of stillbirths remain underexplained or unexplained. Based on our hypothesis that some unexplained stillbirths occur due to repetitive uteroplacental hypoperfusion during periods of maternal supine sleep, we conducted a retrospective review of 17 years of stillbirth fetal autopsies, placental pathology, and maternal clinical histories to determine the correlation between clinical risk factors for increased maternal venous pressure when supine and phasic-type neuropathological findings associated with uteroplacental hypoperfusion.
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